Heterocyclic compounds for the treatment of migraine
US6716837B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | Nov 13, 2000 |
| Grant date | Apr 6, 2004 |
| Priority date | — |
| Expiry date | Nov 13, 2020 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D471/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Described herein are compounds useful in the treatment of migraine, which have the general formula: wherein:W is a CH group or a N atom; Z is N or C—R4; B and D are selected independently from CH and N, with the proviso that at least one of B and D is CH and with the further proviso that one of B and D can represent N only when W and Z are both other than N; A is a group of Formula II, III or IV, such that group A contains at least 1 N atom; NR7 is either —NH— or —N═; <CUSTOM-CHARACTER FILE="US06716837-20040406-P00900.TIF" ALT="custom character" HE="20" WI="20" ID="CUSTOM-CHARACTER-00001"/> is a single or double bond; X is a N atom, a CH group or a C(OH) group when <CUSTOM-CHARACTER FILE="US06716837-20040406-P00900.TIF" ALT="custom character" HE="20" WI="20" ID="CUSTOM-CHARACTER-00002"/> is a single bond; or, when <CUSTOM-CHARACTER FILE="US06716837-20040406-P00900.TIF" ALT="custom character" HE="20" WI="20" ID="CUSTOM-CHARACTER-00003"/> is a double bond, a C atom; Y is an NH, N-alkyl, N-benzyl or CH2 group; U and V each represent a N atom or a CH group, with the proviso that both cannot be N; a and b are, independently, 0 or 1; c is an integer from 0 to…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.