Virus-like particles for the induction of autoantibodies

US6719978B2 · kind B2 · utility

Assignee

• The United States of America, as represented by the Department of Health and Human Services · US

Inventors

• John T. Schiller · Silver Spring, US
• Bryce Chackerian · Albuquerque, US
• Douglas R. Lowy · Washington, US

Key dates

• Filing date: Apr 13, 2001
• Grant date: Apr 13, 2004
• Expiry date: Apr 13, 2021

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2710/22023
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention described herein relates to compositions and methods for stimulating immune responses in vivo against a tolerogen. Novel biotechnological tools, pharmaceuticals, therapeutics and prophylactics, which concern chimeric or conjugated virus-like particles, and methods of use of the foregoing are provided for the study of B cell tolerance and the treatment or prevention of human diseases, which involve the onset of B cell tolerance, such as chronic viral infection, chronic inflammatory disease, and neoplasia.