Substituted purine derivatives, processes for their preparation, their use, and compositions comprising them

US6723727B1 · kind B1 · utility

Assignees

• Hoechst GmbH · DE
• Genentech, Inc. · US

Inventors

• Anuschirwan Peyman · Kelkheim, DE
• Jochen Knolle · Kriftel, DE
• Volkmar Wehner · Bischofsheim a.d.Rhön, DE
• Gerhard Breipohl · Scheinfeld, DE
• Jean-Francois Gourvest · Claye-Souilly, FR
• Denis Carniato · Marcoussis, FR
• Thomas Gadek · Oakland, US

Key dates

• Filing date: Jun 15, 2000
• Grant date: Apr 20, 2004
• Expiry date: Oct 1, 2020

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P35/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to compounds of the formulae I and Ia in which X, Y, W, Wa, G and Ga have the meanings given in the patent claims, and their physiologically tolerable salts and their prodrugs, their preparation, their use, in particular as pharmaceutical active compounds, and pharmaceutical preparations comprising them. The compounds of the formula I are vitronectin receptor antagonists and can be employed, for example, as inhibitors of bone resorption and for the treatment of osteoporosis.