Process for the preparation of baccatin III analogs bearing new C2 and C4 functional groups
US6727369B1 · kind B1 · utility
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56Claims
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Key dates
| Filing date | Apr 14, 1995 |
| Grant date | Apr 27, 2004 |
| Priority date | — |
| Expiry date | Apr 13, 2020 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D305/14
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Process for the preparation of a derivative or analog of baccatin III or 10-desacetyl baccatin III having a C2 substituent other than benzoate and/or a C4 substituent other than acetate in which the C2 benzoate substituent and/or the C4 acetate substituent of a derivative of baccatin III or 10-desacetyl baccatin III is/are selectively reduced to the corresponding hydroxy group(s) and converted to R7COO— and/or R8COO—, respectively, wherein R7 and R8 are independently H, C1-C6 alkyl, C2-C6 alkenyl, C2-C8 alkynyl, moncyclic aryl, or monocyclic heteroaryl.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.