Pyrazino-pyridazine derivatives as ligands for GABA receptors
US6730676B2 · kind B2 · utility
2Cited by
2References
9Claims
0Family size
Assignee
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Key dates
| Filing date | Jun 18, 2002 |
| Grant date | May 4, 2004 |
| Priority date | — |
| Expiry date | Jun 29, 2022 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P43/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A class of pyrazino[2,3-d]pyridazine derivatives, possessing an optionally substituted cycloalkyl, phenyl or heteroaryl substituent at the 5-position, a substituted alkoxy moiety at the 3-position, and a range of substituents at the 2-position, are selective ligands for GABAA receptors, in particular having high affinity for the &agr;2 and/or &agr;3 and/or &agr;5 subunit thereof, and are accordingly of benefit in the treatment and/or prevention of adverse conditions of the central nervous system, including anxiety, convulsions and cognitive disorders.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.