Triazolo-pyrimidine derivatives as ligands for gaba receptors
US6730681B2 · kind B2 · utility
4Cited by
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12Claims
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Key dates
| Filing date | Jun 14, 2002 |
| Grant date | May 4, 2004 |
| Priority date | — |
| Expiry date | Jun 14, 2022 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P25/22
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A class of substituted or 6,7-ring fused [1, 2, 3]triazolo[1,5-&agr;]-pyrimidine derivatives, possessing an optionally substituted cycloalkyl, phenyl or heteroaryl substituent at the 3-position and an amino moiety at the 5-position, are selective ligands for GABAA receptors, in particular having high affinity for the &agr;2 and/or &agr;3 subunit thereof, and are accordingly of benefit in the treatment and/or prevention of disorders of the central nervous system, including anxiety and convulsions.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.