Methods and compositions for transforming dendritic cells and activating T cells
US6734014B1 · kind B1 · utility
23Cited by
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37Claims
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Key dates
| Filing date | Jan 7, 1999 |
| Grant date | May 11, 2004 |
| Priority date | — |
| Expiry date | Jan 7, 2019 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2501/23
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Recombinant dendritic cells are made by transforming a stem cell and differentiating the stem cell into a dendritic cell. The resulting dendritic cell is an antigen presenting cell which activates T cells against MHC class I-antigen targets. Kits, assays and therapeutics are based upon the activation of T cells by the recombinant dendritic cell. Cancer, viral infections and parasitic infections are all ameliorated by the recombinant dendritic cells, or corresponding activated T cells. Therapeutic compositions and pharmaceutical compositions are provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.