D-proline derivatives

US6740760B2 · kind B2 · utility

Assignee

• Hoffmann-La Roche Inc. · US

Inventors

• Cornelia Hertel · Münchenstein, CH
• Torsten Hoffmann · Weil am Rhein, DE
• Roland Jakob-Roetne · Inzlingen, DE
• Roger Norcross · Olsberg, CH

Key dates

• Filing date: Jul 1, 2002
• Grant date: May 25, 2004
• Expiry date: Jul 1, 2022

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D419/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

New compounds have the formula: wherein R, R1, X and Y have the meanings described herein. Methods are set forth for synthesizing these compounds and using these compounds to treat diseases associated with amyloidosis, such as Alzheimer's disease, maturity onset diabetes mellitus, familial amyloid polyneuropathy, scrapie, and Kreuzfeld-Jacob disease.