Cyclic &bgr;-amino acid derivatives as inhibitors of matrix metalloproteases and TNF-&agr;

US6743807B2 · kind B2 · utility

Assignee

• Bristol-Myers Squibb Pharma Company · US

Inventors

• Jingwu Duan · Yardley, US
• Gregory R. Ott · West Chester, US
• Lihua Chen · Boothwyn, US
• Carl P. Decicco · New Hope, US
• Zhonghui Lu · King of Prussia, US
• Thomas P. Maduskuie, Jr. · Wilmington, US
• Chu-Biao Xue · Hockessin, US

Key dates

• Filing date: Mar 16, 2001
• Grant date: Jun 1, 2004
• Expiry date: Dec 10, 2021

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2601/08
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present application describes novel cyclic &bgr;-amino acid derivatives of formula I: or pharmaceutically acceptable salt forms thereof, wherein ring B is a 5-7 membered cyclic system containing from 0-2 heteroatoms selected from O, N, NRa, and S(O)p, and 0-1 carbonyl groups and the other variables are defined in the present specification, which are useful as metalloprotease and/or as TNF-&agr; inhibitors.