Chemical modification of DNA using peptide nucleic acid conjugates
US6746868B1 · kind B1 · utility
1Cited by
2References
6Claims
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Key dates
| Filing date | Nov 3, 2000 |
| Grant date | Jun 8, 2004 |
| Priority date | — |
| Expiry date | Feb 1, 2021 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2710/16622
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Complexes comprising a nucleic acid molecule and a conjugated peptide nucleic acid (PNA). The PNA may be labeled or conjugated to a protein, peptide, carbohydrate moiety or receptor ligand. These complexes are used to transfect cells to monitoring plasmid biodistribution, promote nuclear localization, induce transcriptional activation, lyse the endosomal compartment and facilitate transfection. These complexes increase the efficiency of expression of a particular gene.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.