Sodium channel modulators

US6756400B2 · kind B2 · utility

Assignee

• Theravance, Inc. · US

Inventors

• Jason P. Chinn · Petaluma, US
• Seok-Ki Choi · Ann Arbor, US
• Paul R. Fatheree · San Francisco, US
• Daniel Marquess · Rue de l'Église, US
• S. Derek Turner · Reston, US

Key dates

• Filing date: Aug 30, 2001
• Grant date: Jun 29, 2004
• Expiry date: Nov 9, 2021

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D453/02
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention provides sodium channel modulating compounds of formula I: wherein X, Y, Q, R1, w, and R2 have any of the values defined in the specification, and salts thereof, which are useful for treating diseases or conditions associated with sodium channel activity, such as neuropathic pain. The invention also provides pharmaceutical compositions comprising a compound of formula (I) or a salt thereof, as well as therapeutic methods comprising administering such a compound or salt to a mammal (e.g. a human).