Thiazole compounds useful as inhibitors of protein kinase

US6762179B2 · kind B2 · utility

Assignee

• Vertex Pharmaceuticals Incorporated · US

Inventors

• John Cochran · North Andover, US
• Suganthini S. Nanthakumar · Newton, US
• Edmund Harrington · Plymouth, US
• Jian Wang · Newton, US

Key dates

• Filing date: May 23, 2002
• Grant date: Jul 13, 2004
• Expiry date: Jul 19, 2022

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F9/6561
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides a compound of formula I: or a pharmaceutically acceptable derivative thereof, wherein Ar1 is phenyl and R1 is as defined in the specification. These compounds are inhibitors of protein kinases, particularly inhibitors of GSK3, Aurora2, and Syk mammalian protein kinases. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of utilizing those compounds and compositions in the treatment of various protein kinase mediated disorders.