Long wave fluorophore sensor compounds and other fluorescent sensor compounds in polymers

US6766183B2 · kind B2 · utility

Assignees

• MEDTRONIC MINIMED, INC. · US
• The Regents of the University of California · US

Inventors

• Joseph C. Walsh · Santa Monica, US
• Aaron M. Heiss · West Hollywood, US
• Glenn Noronha · Atlanta, US
• David J. Vachon · San Fernando, US
• Stephen M. Lane · Oakland, US
• Joe H. Satcher, Jr. · Patterson, US
• Thomas A. Peyser · Menlo Park, US
• William P. Van Antwerp · Valencia, US
• John J. Mastrototaro · Los Angeles, US

Key dates

• Filing date: Dec 28, 2001
• Grant date: Jul 20, 2004
• Expiry date: Jan 5, 2023

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10T436/144444
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

Fluorescent biosensor molecules, fluorescent biosensors and systems, as well as methods of making and using these biosensor molecules and systems are described. Embodiments of these biosensor molecules exhibit fluorescence emission at wavelengths greater than about 650 nm. Typical biosensor molecules include a fluorophore that includes an iminium ion, a linker moiety that includes a group that is an anilinic type of relationship to the fluorophore and a boronate substrate recognition/binding moiety, which binds glucose. The fluorescence molecules modulated by the presence or absence of polyhydroxylated analytes such as glucose. This property of these molecules of the invention, as well as their ability to emit fluorescent light at greater than about 650 nm, renders these biosensor molecules particularly well-suited for detecting and measuring in-vivo glucose concentrations.