Substituted tetrahydroisoquinolines as C5a receptor modulators
US6777422B2 · kind B2 · utility
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20Claims
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Key dates
| Filing date | Mar 27, 2003 |
| Grant date | Aug 17, 2004 |
| Priority date | — |
| Expiry date | Mar 27, 2023 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D495/04
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Substituted tetrahydroisoquinolines and related compounds are provided. Such compounds are ligands that may be used to modulate C5a receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with pathological C5a receptor activation in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for using them to treat such disorders are provided, as are methods for using such ligands for receptor localization studies.
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