Tetrahydropyridine derivatives, their preparation and their use as cell proliferation inhibitors

US6800638B2 · kind B2 · utility

Assignee

• Hoffmann-La Roche Inc. · US

Inventors

• Guy Georges · Habach, DE
• Adelbert Grossman · Murnau am Staffelsee, DE
• Olaf Mundigl · Weilheim, DE
• Wolfgang von der Saal · Rosenheim, DE
• Tim Sattelkau · Ludwigshafen, DE

Key dates

• Filing date: Jun 23, 2003
• Grant date: Oct 5, 2004
• Expiry date: Jul 17, 2023

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D217/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A compound of the formula (I) wherein A, R1, R2 and X have the meanings defined in the specification, process of manufacturing such as compound and a pharmaceutical composition with HDAC inhibitor activity and anti-cell proliferation activity containing such a compound.