Pyridine and quinoline derivatives

US6800650B2 · kind B2 · utility

Assignee

• Hoffmann-La Roche Inc. · US

Inventors

• Markus Boehringer
• Bernd Loeffler · Oberrimsingen, DE
• Jens-Uwe Peters · Weil am Rhein, DE
• Claus Riemer · Glückstadt, DE
• Peter Weiss · Basel, CH

Key dates

• Filing date: Feb 11, 2003
• Grant date: Oct 5, 2004
• Expiry date: Feb 11, 2023

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D495/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides compounds of formula (I) wherein R1, R2, R3 and R4 are as defined in the specification, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with DPP IV, such as diabetes, particularly non-insulin dependent diabetes mellitus, and impaired glucose tolerance.