Variants of native growth hormones having non naturally occurring amino acid sequences or covalent modifications
US6800740B1 · kind B1 · utility
58Cited by
9References
25Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jun 7, 1995 |
| Grant date | Oct 5, 2004 |
| Priority date | — |
| Expiry date | Jul 29, 2018 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/61
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Growth hormones contain two receptor binding sites termed site 1 and site 2 with which they form ternary complexes with their receptors. In this scheme, site 1 on the hormone binds to one molecule of receptor and then site 2 binds to another molecule of receptor, thereby producing a 1:2 complex. Disclosed herein are growth hormone variants consisting of modifications to the native sequence in the region of site 1 or site 2, or alternatively a combination of modifications at both site 1 and site 2.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.