Multi-dimension liquid chromatography separation system
US6802967B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Mar 6, 2002 |
| Grant date | Oct 12, 2004 |
| Priority date | — |
| Expiry date | Mar 6, 2022 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2030/8411
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Liquid chromatography based on the difference of two or more kinds of separation modes, (e.g., chemical or physical properties of analytes) may improve separations when samples contain complex mixtures. In this invention, the analytes separated on the 1st analysis system (consisting of the 1st column and the 1st mobile phase) will be trapped onto individual trapping columns. Then the trapped analytes will be loaded onto the 2nd analysis system consisting of the 2nd column and the 2nd mobile phase. This invention has the trapping and loading mechanism consisting of a combination of switching valves necessary to produce the serial separations. Also this invention has the capability to affect online desalting when it is needed depending on a detector or the nature of the analyte mixture.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.