Carbamic acid derivatives

US6803381B1 · kind B1 · utility

Assignee

• Hoffmann-La Roche Inc. · US

Inventors

• Konrad Bleicher · Glückstadt, DE
• Vincent Mutel · Mulhouse, FR
• Eric Vieira · Frenkendorf, CH
• Jurgen Wichmann · Steinen, DE
• Thomas Woltering · Freiburg (Elbe), DE

Key dates

• Filing date: May 14, 2003
• Grant date: Oct 12, 2004
• Expiry date: May 14, 2023

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2601/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to compounds of formula whereinR1 is hydrogen or lower alkyl;R2, R2′ are each independently hydrogen, lower alkyl, lower alkoxy, halogen or trifluoromethyl;X is O, S or two hydrogen atoms not forming a bridge;A1/A2 is phenyl;B is a group of formula  whereinR3 is lower alkyl, lower alkenyl, lower alkinyl, benzyl, lower alkyl-cycloalkyl, lower alkyl-cyano, lower alkyl-pyridinyl, lower alkyl-lower alkoxy-phenyl, lower alkyl-phenyl, which is optionally substituted by lower alkoxy, or phenyl, which is optionally substituted by lower alkoxy, or lower alkyl-thienyl, cycloalkyl, lower alkyl-trifluoromethyl or lower alkyl-morpholinyl;Y is —O—, —S— or a bond; andZ is —O—; or a pharmaceutically acceptable salt thereof. These compounds are useful for the control or prevention of acute and/or chronic neurological disorders.