Ligands for FPR class receptors that induce a host immune response to a pathogen or inhibit HIV infection

US6808877B2 · kind B2 · utility

Assignee

• The United States of America, as represented by the Department of Health and Human Services · US

Inventors

• Ji Wang · Castro Valley, US
• Yingying Le · Frederick, US
• WangHua Gong · Frederick, US
• Bao Qun Li · Frederick, US
• Thomas E. Rogers · Ballwin, US
• Philip M. Murphy · Rockville, US
• Joost Oppenheim · Bethesda, US

Key dates

• Filing date: Jul 17, 2002
• Grant date: Oct 26, 2004
• Expiry date: Jul 17, 2022

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2500/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to the discovery of molecules that inhibit viral infection and promote a host immune response to a pathogen. More specifically, the invention disclosed herein concerns molecules that interact with a FPR class receptor, inhibit HIV infection, and stimulate an inflammatory response in a subject. Embodiments of the invention include biotechnological tools, prophylactics, therapeutics, and methods of use of the foregoing, for the study, treatment, and prevention of HIV infection and the induction of an inflammatory response in a subject.