Methods for administration of recombinant gene delivery vehicles for treatment of hemophilia and other disorders
US6818439B1 · kind B1 · utility
55Cited by
8References
20Claims
0Family size
Assignee
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Key dates
| Filing date | Dec 30, 1997 |
| Grant date | Nov 16, 2004 |
| Priority date | — |
| Expiry date | Dec 30, 2017 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2740/13043
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Methods are provided for obtaining measurable levels of a protein, nucleic acid molecule, or enzymatic product in a bodily fluid or cells of a human, comprising the step of administering to a human a recombinant retroviral preparation having a titer on HT1080 cells of greater than 105 cfu/ml, wherein the recombinant retroviral preparation is capable of directing the expression of a protein, nucleic acid molecule, or enzyme which generates an enzymatic product, such that measurable levels of the protein, nucleic acid molecule, or enzymatic product may be obtained in the bodily fluid or cells of the human.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.