Synthesis of 4-[(Z)-4-bromophenyl)(ethoxyimino) methyl]-1'-[(2,4-dimethyl-1-oxido-3-pyridinyl)carbony)]-4'-methyl-1,4-′bipiperidine

US6818773B2 · kind B2 · utility

Assignee

• SCHERING CORPORATION · US

Inventors

• Minzhang Chen · Acton, US
• Bosco D'Sa · Edison, US
• William W. Leong · Westfield, US
• Tong Gan · New Brunswick, US
• George S. K. Wong · Summit, US
• Suhan Tang · Edison, US
• Christopher Nielsen · Westfield, US

Key dates

• Filing date: Oct 11, 2002
• Grant date: Nov 16, 2004
• Expiry date: Apr 25, 2023

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D401/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

In one embodiment, the present invention describes the synthesis of 4-[(Z)-(4-bromophenyl)(ethoxyimino)methyl]-1′-[(2,4-dimethyl-1-oxido-3-pyridinyl)carbonyl]-4′-methyl-1,4′-bipiperidine, and intermediates therefor from easily available starting materials by a simple route.