Patent · US Expired

Camptothecin compounds with a thioether group

US6825206B1 · kind B1 · utility

2Cited by

8References

8Claims

0Family size

Assignees

Research Triangle Institute · US
Duke University · US
National Institutes of Health, Office of Technology Transfer · US

Inventors

Michael P. Gamcsik · Chapel Hill, US
David J. Adams · Warren, US
O. Michael Colvin · Baltimore, US
Monroe E. Wall · Chapel Hill, US
Mansukh C. Wani · Durham, US
Govindarajan Manikumar · Raleigh, US
Yves Pommier · Bethesda, US

Key dates

Filing date	Nov 16, 2000
Grant date	Nov 30, 2004
Priority date	—
Expiry date	Nov 16, 2020

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61K38/00
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Camptothecin compounds which are effective anti-tumor compounds are disclosed. These conjugates inhibit the enzyme topoisomerase I and enhance the stability of the topoisomerase I-DNA cleavable complex.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.