Methods for designing inhibitors of serine/threonine kinases and tyrosine kinases
US6849716B1 · kind B1 · utility
4Cited by
1References
2Claims
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Assignee
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Key dates
| Filing date | Aug 18, 2000 |
| Grant date | Feb 1, 2005 |
| Priority date | — |
| Expiry date | Oct 19, 2021 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/9121
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The invention relates to methods for designing inhibitors of serine/threonine kinases and tyrosine kinases, particularly MAP kinases, through the use of ATP-binding site mutants of those kinases. The methods of this invention take advantage of the fact that the mutant kinases are capable of binding inhibitory compounds of other kinases with greater affinity than the corresponding wild-type kinase. The invention further relates to the mutant kinases themselves and crystallizable co-complexes of the mutant kinase and the inhibitory compound.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.