Identification of the domain of Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) that mediates adhesion to chondroitin sulfate A

US6855323B2 · kind B2 · utility

Assignee

• The United States of America, as represented by the Department of Health and Human Services · US

Inventors

• Artur Scherf · Paris, FR
• Louis Miller · Bethesda, US
• Benoit Gamain · Washington, US
• Dror I. Baruch · Rockville, US
• Pierre Buffet · Paris, FR
• Christine Scheidig · Savigny-le-Temple, FR
• Jurg Gysin · Tarare, FR
• Bruno Pouvelle · Philadelphia, US
• Nobutaka Fujii · Otsu, JP
• Joseph Smith · Fort Collins, US

Key dates

• Filing date: Feb 21, 2002
• Grant date: Feb 15, 2005
• Expiry date: Jul 9, 2022

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to the discovery of a var gene and corresponding protein that modulates adhesion of parasitized red blood cells to chondroitin sulfate A. Novel biological tools, prophylactics, therapeutics, diagnostics, and methods of use of the foregoing are also disclosed.