DPP IV inhibitors

US6861440B2 · kind B2 · utility

Assignee

• Hoffmann-La Roche Inc. · US

Inventors

• Markus Boehringer
• Daniel Hunziker
• Holger Kuehne · Soest, DE
• Bernd Loeffler · Oberrimsingen, DE
• Ramakanth Sarabu · Towaco, US
• Hans Peter Wessel · Heitersheim, DE

Key dates

• Filing date: Oct 14, 2002
• Grant date: Mar 1, 2005
• Expiry date: Oct 14, 2022

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K9/4825
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to compounds of formula (I) wherein R1, R2, and X are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with DPP IV, such as diabetes, particularly non-insulin dependent diabetes mellitus, and impaired glucose tolerance.