Compositions and methods for in vivo delivery of polynucleotide-based therapeutics
US6875748B2 · kind B2 · utility
45Cited by
43References
60Claims
0Family size
Assignee
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Key dates
| Filing date | Apr 23, 2001 |
| Grant date | Apr 5, 2005 |
| Priority date | — |
| Expiry date | Apr 23, 2021 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02A50/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to pharmaceutical compositions and methods to improve expression of exogenous polypeptides into vertebrate cells in vivo, utilizing delivery of polynucleotides encoding such polypeptides. More particularly, the present invention provides the use of salts, in particular sodium and potassium salts of phosphate, in aqueous solution, and auxiliary agents, in particular detergents and surfactants, in pharmaceutical compositions and methods useful for direct polynucleotide-based polypeptide delivery into the cells of vertebrates.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.