Vical Incorporated
70Patents
28Active
70Granted
47Portfolio score
Filing activity: Jun 28, 1989 → Sep 12, 2014 · 15 expiring within 5 years
Most-cited patents
| Patent | Title | Area | Cited by | Status |
|---|---|---|---|---|
| US5580859A | Delivery of exogenous DNA sequences in a mammal | Chemistry; Metallurgy | 1,158 | Expired |
| US5589466A | Induction of a protective immune response in a mammal by injecting a DNA sequence | Chemistry; Metallurgy | 836 | Expired |
| US5459127A | Cationic lipids for intracellular delivery of biologically active molecules | Human Necessities | 573 | Expired |
| US5264618A | Cationic lipids for intracellular delivery of biologically active molecules | Human Necessities | 521 | Expired |
| US5703055A | Generation of antibodies through lipid mediated DNA delivery | Chemistry; Metallurgy | 416 | Expired |
| US6214804A | Induction of a protective immune response in a mammal by injecting a DNA sequence | Chemistry; Metallurgy | 354 | Expired |
| US5223263A | Liponucleotide-containing liposomes | Chemistry; Metallurgy | 274 | Expired |
| US5194654A | Lipid derivatives of phosphonoacids for liposomal incorporation and method of use | Chemistry; Metallurgy | 256 | Expired |
| US5693622A | Expression of exogenous polynucleotide sequences cardiac muscle of a mammal | Performing Operations; Transporting | 221 | Expired |
| US6147055A | Cancer treatment method utilizing plasmids suitable for IL-2 expression | Chemistry; Metallurgy | 133 | Expired |
| US6696424B1 | Cytofectin dimers and methods of use thereof | Chemistry; Metallurgy | 124 | Expired |
| US6413942B1 | Methods of delivering a physiologically active polypeptide to a mammal | Chemistry; Metallurgy | 121 | Expired |
| US7268120B1 | Methods for treating cancer using cytokine-expressing polynucleotides | Human Necessities | 107 | Expired |
| US7250404B2 | Lipid-mediated polynucleotide administration to deliver a biologically active peptide and to induce a cellular immune response | Chemistry; Metallurgy | 78 | Expired |
| US5910488A | Plasmids suitable for gene therapy | Chemistry; Metallurgy | 69 | Expired |
| US5561064A | Production of pharmaceutical-grade plasmid DNA | Chemistry; Metallurgy | 51 | Expired |
| US6586409B1 | Adjuvant compositions and methods for enhancing immune responses to polynucleotide-based vaccines | Emerging Cross-Sectional Technologies | 49 | Expired |
| US5846946A | Compositions and methods for administering Borrelia DNA | Emerging Cross-Sectional Technologies | 47 | Expired |
| US6875748B2 | Compositions and methods for in vivo delivery of polynucleotide-based therapeutics | Emerging Cross-Sectional Technologies | 45 | Expired |
| US5861397A | Piperazine based cytofectins | Emerging Cross-Sectional Technologies | 42 | Expired |
| US6022874A | Piperazine based cytofectins | Emerging Cross-Sectional Technologies | 41 | Expired |
| US5707812A | Purification of plasmid DNA during column chromatography | Chemistry; Metallurgy | 40 | Expired |
| US7628993B2 | Compositions and methods for vaccinating against HSV-2 | Chemistry; Metallurgy | 39 | Active |
| US5641665A | Plasmids suitable for IL-2 expression | Chemistry; Metallurgy | 35 | Expired |
| US7537768B2 | Influenza virus vaccine composition and methods of use | Chemistry; Metallurgy | 34 | Active |
Source: USPTO / EPO open patent data. Counts and citation impact are objective bibliographic measures.