Nitric oxide-releasing metallic medical devices

US6887485B2 · kind B2 · utility

Assignees

• Medtronic Vascular, Inc. · US
• The United States of America, as represented by the Department of Health and Human Services · US

Inventors

• Anthony L. Fitzhugh · Frederick, US
• Peiwen Cheng · Santa Rosa, US
• Joseph E. Saavedra · Thurmont, US
• Robert Cafferata · Santa Rosa, US
• Marc Hendriks · Brunssum, NL
• Larry K. Keefer · Bethesda, US
• Eugene Tedeschi · Santa Rosa, US
• Michel Verhoeven · Eijsden, NL

Key dates

• Filing date: May 25, 2001
• Grant date: May 3, 2005
• Expiry date: May 25, 2021

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61L2300/602
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Biocompatible metallic medical devices having silanized surfaces coupled to nucleophile residues that release sustained, therapeutic amounts of nitric oxide to specific sites within a mammalian body are provided. Additionally, the biocompatible metallic medical devices can also be provided with anti-thrombogenic, lubricious coatings that release sustained, therapeutic amounts of nitric oxide. Moreover, the silanized metallic devices are surprisingly durable when exposed to harsh chemical methods often needed to bind nitric oxide-releasing functional groups to nucleophile residues. Furthermore, methods are provided for producing stable, silanized, sustained nitric oxide-releasing metallic medical devices.