Process for the preparation of {2-[4-α-phenyl-p-chlorobenzyl)piperazin-1-yl]ethoxy} acetic acid and novel intermediates therefor
US6908999B2 · kind B2 · utility
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3Claims
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Key dates
| Filing date | Nov 29, 2000 |
| Grant date | Jun 21, 2005 |
| Priority date | — |
| Expiry date | Mar 16, 2021 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P37/08
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The invention refers to a novel process for the preparation of {2-[-(α-phenyl-p-chlorobenzyl)piperazin-1-yl]ethoxy}acetic acid, which comprises hydrolyzing an N,N-disubstituted {2-[-(α-phenyl-p-chlorobenzyl)piperazin-1-yl]ethoxy}acetamide, wherein said substituents are selected from alkyl groups having 1 to 4 carbon atoms optionally substituted by a phenyl group, alkenyl groups having 2 to 4 carbon atoms or cyclohexyl groups, or the substituents together with the adjacent nitrogen atom of the acetoamido group, form a morpholino group.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.