Antibodies that bind gamma-heregulin
US6916624B2 · kind B2 · utility
3Cited by
3References
4Claims
0Family size
Assignee
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Key dates
| Filing date | Nov 8, 2002 |
| Grant date | Jul 12, 2005 |
| Priority date | — |
| Expiry date | Dec 13, 2023 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S435/971
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A novel member of the heregulin superfamily has been identified which is designated “γ-HRG”. This molecule, secreted by human breast cancer MDA-MB-175 cells, leads to the formation of a constitutive active receptor complex and stimulates the growth of these cells in an autocrine manner. γ-HRG polypeptide and nucleic acid are disclosed, together with various uses therefor (e.g. use of γ-HRG nucleic acid for the recombinant production of γ-HRG). γ-HRG antagonists (e.g. neutralizing antibodies and antisense nucleic acid molecules) as well as uses therefor are also described.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.