Serine protease inhibitors

US6919369B2 · kind B2 · utility

Assignee

• Genentech, Inc. · US

Inventors

• Ignacio Aliagas-Martin · San Francisco, US
• Dean R. Artis · Kensington, US
• Michael S. DINA · Daly City, US
• John A. Flygare · Burlingame, US
• Richard Goldsmith · Belmont, US
• Regina Munroe · San Mateo, US
• Alan G. Olivero · South San Francisco, US
• Richard Pastor · South San Francisco, US
• Thomas E. Rawson · Mountain View, US
• Kirk Robarge · San Francisco, US
• Daniel P. Sutherlin · Redwood City, US
• Kenneth Weese · South San Francisco, US
• Aihe Zhou · San Jose, US
• Yan Zhu · Beijing, CN

Key dates

• Filing date: Aug 19, 2002
• Grant date: Jul 19, 2005
• Expiry date: Aug 17, 2023

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C311/51
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds having the structure shown below are useful to inhibit serine protease enzymes, such as TF/factor VIIa, factor Xa, thrombin and kallikrein. These compounds may be used in methods of preventing and/or treating clotting disorders.