Chip-based species identification and phenotypic characterization of microorganisms

US6924094B1 · kind B1 · utility

Assignee

• AFFYMETRIX, INC. · US

Inventors

• Thomas Gingeras · Encinitas, US
• David Mack · Menlo Park, US
• Mark S. Chee · Encinitas, US
• Anthony Berno · San Jose, US
• Lubert Stryer · Stanford, US
• Ghassan Ghandour · Atherton, US
• Ching-Ho Wang · Taipei, TW

Key dates

• Filing date: Nov 28, 2000
• Grant date: Aug 2, 2005
• Expiry date: Dec 4, 2020

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Q2600/156
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

This invention provides oligonucleotide based arrays and methods for speciating and phenotyping organisms, for example, using oligonucleotide sequences based on the Mycobacterium tubercluosis rpoB gene. The groups or species to which an organism belongs may be determined by comparing hybridization patterns of target nucleic acid from the organism to hybridization patterns in a database.