Monoclonal antibodies specific for the E2 glycoprotein of hepatitic C virus and their use in the diagnosis, treatment, and prevention of hepatitis C

US6924362B2 · kind B2 · utility

Assignee

• The United States of America, as represented by the Department of Health and Human Services · US

Inventors

• Darren Schofield · Melbourn, GB
• Suzanne U. Emerson · Rockville, US
• Robert H. Purcell · Boyds, US
• Harvey J. Alter · Ambler, US

Key dates

• Filing date: Nov 30, 2001
• Grant date: Aug 2, 2005
• Expiry date: Nov 30, 2021

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2333/18
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

The present invention describes the identification and characterization of five human HC E1-specific monoclonal antibodies isolated from a phage display library and their use in the diagnosis, treatment, and prevention of HCV in mammals, preferably humans.