In vivo animal model of human leukemia
US6930222B2 · kind B2 · utility
9Cited by
3References
9Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Aug 22, 2001 |
| Grant date | Aug 16, 2005 |
| Priority date | — |
| Expiry date | Jun 29, 2022 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA01K2267/0331
- WIPO fieldOther special machines
- WIPO sectorMechanical engineering
Abstract
The present invention provides a process for making an in vivo model of human leukemia. The process includes the steps of: pre-conditioning an immunodeficient rodent by administering to the rodent a sub-lethal dose of irradiation and injecting the rodent with an effective pre-conditioning amount of human fetal cord blood mononuclear cells; maintaining the rodent for from about 5 to 10 days; and injecting the rodent with an effective engrafting amount of primary human leukemia cells. An in vivo and in vitro model of human leukemia are also provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.