Derivatives of dicarboxylic acid having pharmaceutical properties

US6939990B2 · kind B2 · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Michael Härter · Wixom, US
• Michael Hahn · Langenfeld, DE
• Claudia Hirth-Dietrich · Wuppertal, DE
• Andreas Knorr · Erkrath, DE
• Elke Stahl · Bensberg, DE
• Johannes-Peter Stasch · Wuppertal, DE
• Frank Wunder · Wuppertal, DE

Key dates

• Filing date: Feb 18, 2002
• Grant date: Sep 6, 2005
• Expiry date: Feb 18, 2022

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2601/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to compounds of the general formula (I) wherein R1 represents H, halogen, or OCF3; R2 and R3 each represents H or halogen; R4 represents C1-6-alkyl, C3-8-cycloalkyl, CF3, OCF3, F, Cl, OMe, or optionally substituted phenyl; V represents O, CH2O, OCF2, or O—C1-6-alkyl-O; and W represents CH2 or CH2CH2. A process for making such compounds, pharmaceutical compositions containing them, and methods of treatment of various conditions using them are also disclosed and claimed.