Substituted pyrazolyl compounds for the treatment of inflammation

US6956052B2 · kind B2 · utility

Assignee

• Pharmacia Corporation · SE

Inventors

• Arija A. Bergmanis · Plainfield, US
• Michael Clare · Skokie, US
• Joyce Z. Crich · Glenview, US
• Lifeng Geng · Skokie, US
• Timothy J. Hagen · Gurnee, US
• Gunnar J. Hanson · Cambridge, US
• Stephen C. Houdek · Des Plaines, US
• He Huang · Northbrook, US
• Donna Iula · Ann Arbor, US
• Francis J. Koszyk · Prospect Heights, US
• Shuyuan Liao · Northbrook, US
• Scott Mohler · Chicago, US
• Maria Nguyen · Morton Grove, US
• Richard A. Partis · Evanston, US
• Michael A. Stealey · Libertyville, US
• Michael B. Tollefson · Dardenne Prairie, US
• Richard M. Weier · Lake Bluff, US
• Xiangdong Xu · Gurnee, US
• Dominique Bonafoux · Saint Louis, US
• Theresa Fletcher · Kirkwood, US
• Bruce C. Hamper · Kirkwood, US
• Patrick J. Lennon · Webster Groves, US
• Subo Liao · Ballwin, US
• Suzanne Metz · Chesterfield, US
• David Oburn · Ferguson, US
• Thomas Owen · Chesterfield, US
• Angela M. Scates · Des Peres, US
• Michael L. Vazquez · Saint Louis, US
• Serge Wolfson · Chesterfield, US

Key dates

• Filing date: Sep 19, 2002
• Grant date: Oct 18, 2005
• Expiry date: Dec 24, 2022

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to substituted pyrazolyl derivatives, compositions comprising such, intermediates, methods of making substituted pyrazolyl derivatives, and methods for treating cancer, inflammation, and inflammation-associated disorders, such as arthritis.