Method for enhancing contrast produced by MRI

US6963769B1 · kind B1 · utility

Assignee

• The United States of America as Represented by the Secretary of the Department of Health and Human Services · US

Inventors

• Robert S. Balaban · Cambridge, US
• Kathleen M. Ward · Arlington, US
• Anthony H. Aletras · Rockville, US

Key dates

• Filing date: Apr 20, 2000
• Grant date: Nov 8, 2005
• Expiry date: Apr 20, 2020

Classification

• Technology area (CPC G): Physics
• CPC primary: G01R33/5601
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A method for obtaining an image by MRI, comprising: administering at least one contrast agent to a subject in amounts effective to perform CEDST MRI analysis; and performing CEDST MRI analysis to produce an image of the subject. A number of different contast agents can be used to practice the present method including, without limitation, sugars, animo acids, nitrogen-containing heterocycles, purines and pyrimidines, nucleosides; imidazole and derivatives thereof, imino acids, barbituric acid and analogs thereof, and miscellaneous materials, such as guanidine hydantoin, parabanic acid, and biologically active salts thereof.