Oxazole derivatives

US6969725B2 · kind B2 · utility

Assignee

• Hoffmann-La Roche Inc. · US

Inventors

• Alfred Binggeli · Binningen, CH
• Markus Boehringer
• Uwe Grether · Weil am Rhein, DE
• Hans Hilpert · Reinach, CH
• Georges Hirth · Colmar, FR
• Hans-Peter Maerki · Basel, CH
• Markus Meyer · Hannover, DE
• Peter Mohr · Basel, CH
• Fabienne Ricklin · Hombourg, FR

Key dates

• Filing date: Oct 6, 2003
• Grant date: Nov 29, 2005
• Expiry date: Oct 6, 2023

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to compounds of formula (I) wherein wherein R1, R2, R3, R4, R5, R6 and n are as described herein. The compounds of the present invention can be used as medicaments for the treatment and/or prevention of diseases which are modulated by PPARα and/or PPARγ agonists. Examples of such diseases are diabetes, particularly non-insulin dependent diabetes mellitus, elevated blood pressure, increased lipid and cholesterol levels, atherosclerotic diseases, metabolic syndrome, endothelial dysfunction, procoagulant state, dyslipidemia, polycystic ovary syndrome, inflammatory diseases (such as e.g. crown disease, inflammatory bowel disease, collitis, pancreatitis, cholestasis/fibrosis of the liver, and diseases that have an inflammatory component such as e.g. Alzheimer's disease or impaired/improvable cognitive function) and proliferative diseases.