Compositions and methods for treating neoplastic disease using chemotherapy and radiation sensitizers
US6974867B2 · kind B2 · utility
5Cited by
2References
4Claims
0Family size
Assignee
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Key dates
| Filing date | May 30, 2001 |
| Grant date | Dec 13, 2005 |
| Priority date | — |
| Expiry date | May 30, 2021 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2310/11
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Inhibitors of KIAA0175 are provided that reduce the expression or biological activities of KIAA0175, p53 and/or p21 in a mammalian cell. KIAA0175 inhibitors include anti-sense molecules, ribozymes, antibodies and antibody fragments, proteins and polypeptides as well as small molecules. KIAA0175 inhibitors find use in compositions and methods for decreasing KIAA0175, p53 and/or p21 gene expression as well as methods for increasing the chemo and/or radiosensitivity of mammalian cells, including tumor cells, methods for decreasing the side effects of cancer therapy and methods for treating neoplastic diseases.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.