Polyanionic polymers which enhance fusogenicity
US6986902B1 · kind B1 · utility
58Cited by
9References
46Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Apr 27, 1999 |
| Grant date | Jan 17, 2006 |
| Priority date | — |
| Expiry date | Apr 27, 2019 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC08F8/32
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates generally to the amphiphilic polyelectrolyte, poly(2-ethylacrylic acid) and covalently bonded lipids to generate Lipo-PEAA. These Lipo-PEAA are then used to make pH-sensitive liposomes which become unstable, permeable or fusogenic with certain pH changes. In addition, this invention generally describes methods for delivering therapeutic compounds and drugs to target cells by administering to a host the pH-sensitive liposomes of the present invention.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.