Imidazo-triazine derivatives as ligands for gaba receptors
US7005431B2 · kind B2 · utility
18Cited by
2References
10Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | May 1, 2003 |
| Grant date | Feb 28, 2006 |
| Priority date | — |
| Expiry date | May 1, 2023 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P27/16
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A class of 7-phenylimidazo[1,2-b][1,2,4]triazine derivatives, substituted at the meta position of the phenyl ring by an optionally substituted aryl or heteroaryl group which is directly attached or bridged by an oxygen atom or a —NH— linkage, and substituted on the phenyl ring by one or two further substituents as defined herein, being selective ligands for GABAA receptors, in particular having good affinity for the α2 and/or α3 and/or α5 subunit thereof, are accordingly of benefit in the treatment and/or prevention of adverse conditions of the central nervous system, including anxiety, convulsions and cognitive disorders.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.