Isolated peptides which bind to HLA-C molecules and uses thereof

US7009035B2 · kind B2 · utility

Assignees

• LUDWIG INSTITUTE FOR CANCER RESEARCH LTD · GB
• Cornell Research Foundation, Inc. · US
• Memorial Sloan Kettering Cancer Center · US

Inventors

• Sacha Gnjatic · New York, US
• Lloyd J. Old · New York, US
• Yasuhiro Nagata · Kusatsu, JP
• Elke Jager · Frankfurt am Main, DE
• Yao-Tseng Chen · New York, US
• Alexander Knuth · Frankfurt am Main, DE

Key dates

• Filing date: Oct 18, 2002
• Grant date: Mar 7, 2006
• Expiry date: Dec 30, 2023

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention teaches peptide epitopes which bind to HLA-Cw3 and HLA-Cw6 molecules on the surface of cells. The peptides are useful diagnostically and therapeutically, as are DNA molecules which encode them, and the cytolytic T lymphocytes specific to the HLA/peptide complexes. Also a feature of the invention is a method for identifying relevant molecules such as those described herein, in a system that uses stimulation and restimulation using different viral vectors.