5-Substituted pyrimidine derivatives of conformationally locked nucleoside analogues

US7009050B2 · kind B2 · utility

Assignee

• The United States of America, as represented by the Department of Health and Human Services · US

Inventors

• Victor E. Marquez · Gaithersburg, US
• Pamela L. Russ · Great Falls, US

Key dates

• Filing date: Jan 15, 2003
• Grant date: Mar 7, 2006
• Expiry date: Jul 6, 2023

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D239/553
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The embodiments described herein concern 5-substituted pyrimidine derivatives of conformationally locked nucleoside analogues and to the use of these derivatives as anti-viral and anti-cancer agents. The compounds are of the formula: wherein B is uracil-1-yl or cytosin-1-yl having a 5-substituent selected from halogen, alkyl, alkenyl, and alkynyl, with the proviso that where B is uracil-1-yl, the 5-substituent is not methyl. The compounds are useful in the treatment of Herpes simplex virus (HSV).