Patent · US Expired

Immunotherapeutic agents

US7019030B2 · kind B2 · utility

1Cited by

53References

18Claims

0Family size

Assignee

CELGENE CORPORATION · US

Inventors

George W. Muller · Northbrook, US
Mary Shire · North Plainfield, US

Key dates

Filing date	Jul 17, 2003
Grant date	Mar 28, 2006
Priority date	—
Expiry date	Jul 17, 2023

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07C2601/08
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Cyano and carboxy derivatives of substituted styrenes are inhibitors of tumor necrosis factor α, nuclear factor κB, and phosphodiesterase and can be used to combat cachexia, endotoxic shock, retrovirus replication, asthma, and inflammatory conditions. A typical embodiment is 3,3-bis-(3,4-dimethoxyphenyl)acrylonitrile.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.