Formulation, solubilization, purification, and refolding of tissue factor pathway inhibitor
US7022672B2 · kind B2 · utility
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Key dates
| Filing date | Nov 30, 2001 |
| Grant date | Apr 4, 2006 |
| Priority date | — |
| Expiry date | Dec 21, 2022 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K14/8114
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method of modifying protein solubility employs polyionic polymers. These facilitate the solubilization, formulation, purification and refolding of proteins especially incorrectly folded proteins and aggregated proteins. Compositions are described that are suitable for formulating TFPI. The compositions allow preparation of pharmaceutically acceptable compositions of TFPI at concentrations above 0.2 mg/mL and above 10 mg/mL.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.