Pyridine and pyrimidine derivatives

US7022718B2 · kind B2 · utility

Assignee

• Hoffmann-La Roche Inc. · US

Inventors

• Markus Boehringer
• Bernd Loeffler · Oberrimsingen, DE
• Jens-Uwe Peters · Weil am Rhein, DE
• Matthias Steger · Zürich, CH
• Peter Weiss · Basel, CH

Key dates

• Filing date: Jan 18, 2005
• Grant date: Apr 4, 2006
• Expiry date: Jan 18, 2025

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D409/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides compounds of formula (I) wherein R1, R2, R3, R4 and X are as defined in the specification, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with DPP IV, such as diabetes, particularly non-insulin dependent diabetes mellitus, and impaired glucose tolerance.