Polynucleotides encoding GFRα3
US7026138B1 · kind B1 · utility
8Cited by
1References
5Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Mar 19, 1999 |
| Grant date | Apr 11, 2006 |
| Priority date | — |
| Expiry date | Mar 19, 2019 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K14/71
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention relates to nucleotide sequences, including expressed sequence tags (ESTs), oligonucleotide probes, polypeptides, vectors and host cells expressing, and immunoadhesions and antibodies to mammalian GFRα3, a novel α-subunit receptor of the GDNF (i.e. GFR) receptor family. It further relates to an assay for measuring activation of an α-subunit receptor by detecting tyrosine kinase receptor activation (i.e., autophosphorylation) or other activities related to ligand-induced α-subunit receptor homo-dimerization or homo-oligomerization.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.