4-Pyrrolidino-phenyl-benzyl ether derivatives

US7037935B2 · kind B2 · utility

Assignee

• Hoffmann-La Roche Inc. · US

Inventors

• Hans Iding · Rheinfelden (Baden), DE
• Synese Jolidon · Blauen, CH
• Daniela Krummenacher · Rheinfelden, CH
• Rosa Maria Rodriguez-Sarmiento · Basel, CH
• Andrew Thomas · Birsfelden, CH
• Beat Wirz · Basel, CH
• Wolfgang Wostl · Weil am Rhein, DE
• Rene Wyler · Zürich, CH

Key dates

• Filing date: Sep 18, 2003
• Grant date: May 2, 2006
• Expiry date: Sep 18, 2023

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D207/277
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to racemic or enantiomerically pure 4-pyrrolidino derivatives, processes for their preparation, pharmaceutical compositions comprising said derivatives, and their use in the prevention and treatment of illness, in particular which is mediated by monoamine oxidase B inhibitors, in particular Alzheimer's disease or senile dementia.