Process for selectively producing 1-phosphorylated sugar derivative anomer and process for producing nucleoside
US7038039B2 · kind B2 · utility
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26Claims
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Key dates
| Filing date | Feb 13, 2001 |
| Grant date | May 2, 2006 |
| Priority date | — |
| Expiry date | Feb 13, 2021 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H19/20
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A desired isomer is selectively prepared by phosphorolyzing and isomerizing an anomer mixture of a 1-phosphorylated saccharide derivative while crystallizing one of the isomers to displace the equilibrium. Furthermore, using the action of a nucleoside phosphorylase, a nucleoside is prepared from the 1-phosphorylated saccharide derivative obtained and a base with improved stereoselectivity and a higher yield. This process is an anomer-selective process for preparing a 1-phosphorylated saccharide derivative and a nucleoside.
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